Unknown genes from metagenomic studies may be assigned hypothetical functions based on their occurrence across a range of genomic and metagenomic datasets, the environmental and metabolic parameters associated with these data, and any functional annotations for neighboring or co-occurring genes. This figure is an example workflow from the 2010 DOE Systems Biology Knowledgebase Implementation Plan, which describes scientific objectives the Knowledgebase will support in microbial, plant, and metacommunity research areas. This workflow illustrates the steps for achieving metacommunity scientific objective 2, Mine Metagenomic Data to Identify Unknown Genes and Develop Testable Hypotheses about Their Function.
Credit or Source: Office of Biological and Environmental Research of the U.S. Department of Energy Office of Science. science.energy.gov/ber
U.S. DOE. 2010. DOE Systems Biology Knowledgebase Implementation Plan. U.S. Department of Energy Office of Science (p. 84) ( website)