U.S. Department of Energy Office of Biological and Environmental Research

BER Research Highlights


Ionizing Radiation Exposure Stimulates Expression of Clusterin
Published: April 04, 2011
Posted: July 15, 2011

What happens when ionizing radiation passes through biological tissues? DOE researchers at the University of Texas Southwestern Medical Center at Dallas and the Indiana University Simon Cancer Center have shown that low doses of ionizing radiation of 10 cGy or less (about 2–3 times the annual exposure limit for DOE workers) stimulates induction of an extracellular protein, secretory clusterin (sCLU), that clears cell debris and increases cell survival in response to damage. sCLU levels are elevated in various tissues after low-dose radiation exposure and are permanently elevated in many early-stage cancers. The researchers also showed, for the first time, that sCLU expression is related to genomic instability induced by low-dose radiation and in cells with spontaneous genomic instability. The hypothesis tested was that normal cells induce sCLU in a transient manner, whereas persistent damage caused by permanent genomic instability leads to constitutive sCLU expression. The scientists found that up regulation of the sCLU signaling cascade may be an important pro-survival response pathway following radiation exposure as well as in response to constitutive damage induced through genetic instability. The results appeared in the advance online publication of the cancer journal, Oncogene. These findings add important clues to our understanding of radiation responses in normal tissues.

Reference: Goetz, E. M., B. Shankar, Y. Zou, J. C. Morales, X. Luo, S. Araki, R. Bachoo, L. D. Mayo, and D. A. Boothman. 2011. "ATM-Dependent IGF-1 Induction Regulates Secretory Clusterin Expression After DNA Damage and in Genetic Instability," Oncogene, advance online publication 4 April 2011; doi: 10.1038/onc.2011.92.

Contact: Noelle Metting, SC-23.2, (301) 903-8309
Topic Areas:

  • Legacy: Low Dose Radiation, Radiobiology

Division: SC-23.2 Biological Systems Science Division, BER

 

BER supports basic research and scientific user facilities to advance DOE missions in energy and environment. More about BER

Recent Highlights

Aug 24, 2019
New Approach for Studying How Microbes Influence Their Environment
A diverse group of scientists suggests a common framework and targeting of known microbial processes [more...]

Aug 08, 2019
Nutrient-Hungry Peatland Microbes Reduce Carbon Loss Under Warmer Conditions
Enzyme production in peatlands reduces carbon lost to respiration under future high temperatures. [more...]

Aug 05, 2019
Amazon Forest Response to CO2 Fertilization Dependent on Plant Phosphorus Acquisition
AmazonFACE Model Intercomparison. The Science Plant growth is dependent on the availabi [more...]

Jul 29, 2019
A Slippery Slope: Soil Carbon Destabilization
Carbon gain or loss depends on the balance between competing biological, chemical, and physical reac [more...]

Jul 15, 2019
Field Evaluation of Gas Analyzers for Measuring Ecosystem Fluxes
How gas analyzer type and correction method impact measured fluxes. The Science A side- [more...]

List all highlights (possible long download time)