U.S. Department of Energy Office of Biological and Environmental Research

BER Research Highlights

Radioadaptive Response Responsible for Threshold for Deleterious Effects of Radiation?
Published: February 01, 2011
Posted: June 22, 2011

Low-dose radiation-induced adaptive responses have been shown in many cell culture systems to protect against cell death from a subsequent high-dose radiation challenge. The protective role seen in single cells is believed to promote the repair of DNA double-strand breaks, a severe threat to cell survival. DOE researcher Dr. Ya Wang of Emory University and her group have now shown that a particular DNA repair pathway (the non-homologous end-joining pathway) is stimulated by low-dose radiation. Another DNA repair pathway, the homologous recombination repair pathway, has also been studied, and does not seem to be affected. The accumulating evidence for beneficial adaptation initiated by a low dose of ionizing radiation argues in favor of a threshold model for deleterious effects.

Reference: Yu, X., H. Wang, P. Wang, B. P. C. Chen, and Y. Wang. 2011. “The Ku-Dependent Non-Homologous End-Joining Pathway Contributes to Low-Dose Radiation-Stimulated Cell Survival,” Journal of Cellular Physiology 226, 369–74.

Contact: Noelle Metting, SC-23.2, (301) 903-8309
Topic Areas:

  • Legacy: Low Dose Radiation, Radiobiology

Division: SC-23.2 Biological Systems Science Division, BER


BER supports basic research and scientific user facilities to advance DOE missions in energy and environment. More about BER

Recent Highlights

Aug 24, 2019
New Approach for Studying How Microbes Influence Their Environment
A diverse group of scientists suggests a common framework and targeting of known microbial processes [more...]

Aug 08, 2019
Nutrient-Hungry Peatland Microbes Reduce Carbon Loss Under Warmer Conditions
Enzyme production in peatlands reduces carbon lost to respiration under future high temperatures. [more...]

Aug 05, 2019
Amazon Forest Response to CO2 Fertilization Dependent on Plant Phosphorus Acquisition
AmazonFACE Model Intercomparison. The Science Plant growth is dependent on the availabi [more...]

Jul 29, 2019
A Slippery Slope: Soil Carbon Destabilization
Carbon gain or loss depends on the balance between competing biological, chemical, and physical reac [more...]

Jul 15, 2019
Field Evaluation of Gas Analyzers for Measuring Ecosystem Fluxes
How gas analyzer type and correction method impact measured fluxes. The Science A side- [more...]

List all highlights (possible long download time)