p>Cell size is a key factor in initiating cell division in yeasts, and the number and volume of organelles have a profound impact on the function and viability of a cell. Soft X-ray tomography at the Advanced Light Source was used to characterize these parameters in strains of Saccharomyces cerevisiae at each of the key stages in the cell cycle and to determine relationships between cellular and organelle volumes. Results showed that growth of the major organelles—with the notable exception of vacuoles—is strictly regulated in accordance with cell size. Similar ratios were found to be maintained in Schizosaccharomyces pombe and Candida albicans. These experiments will undoubtedly improve our understanding of how cells control their size and that of their component organelles.
Reference: Uchida, M., et al. 2011. “Quantitative Analysis of Yeast Internal Architecture Using Soft X-Ray Tomography,” Yeast 28, 227–36.
SC-23.2 Biological Systems Science Division, BER
Quantifying Decision Uncertainty in Water Management via a Coupled Agent-Based Model
Considering risk perception can improve the representation of human decision-making processes in age [more...]
Projecting Global Urban Area Growth Through 2100 Based on Historical Time Series Data and Future Scenarios
Study provides country-specific urban area growth models and the first dataset on country-level urba [more...]
Calibrating Building Energy Demand Models to Refine Long-Term Energy Planning
A new, flexible calibration approach improved model accuracy in capturing year-to-year changes in bu [more...]
Calibration and Uncertainty Analysis of Demeter for Better Downscaling of Global Land Use and Land Cover Projections
Researchers improved the Demeter model’s performance by calibrating key parameters and establi [more...]
Representation of U.S. Warm Temperature Extremes in Global Climate Model Ensembles
Representation of warm temperature events varies considerably among global climate models, which has [more...]
List all highlights (possible long download time)