U.S. Department of Energy Office of Biological and Environmental Research

BER Research Highlights

Complex Sugar Diet Makes Microbe a Good Candidate for Producing Biofuels
Published: March 07, 2011
Posted: March 17, 2011

Many current biofuel production scenarios involve breaking down biomass into its component sugars and using microbes to convert these sugars into liquid biofuels. However, plant biomass contains long chains of both six- and five-carbon sugars (cellulose and hemicelluloses, respectively) and the commonly used biofuel-producing microbes such as the yeast Saccharomyces cerevisiae or the bacterium Escherichia coli cannot use both sugars simultaneously. Thus, substantial effort and expense is required to separate the sugars prior to conversion to fuels, resulting in reduced overall process efficiency. Now, researchers at the DOE Joint Bioenergy Institute (JBEI) have demonstrated that the microbe Sulfolobus acidocaldarius can simultaneously consume both types of sugars, efficiently consuming even complex substrate mixtures. S. acidocaldarius is an extremophile capable of growing at high temperatures in acidic conditions with an unusually high degree of genome stability. Altogether, these traits make this organism an attractive candidate for metabolic engineering and further development as industrial biofuel producer.

Reference: Joshua, C. J., R. Dahl, P. I. Benke, and J. D. Keasling. 2011. “Absence of Diauxie During Simultanteous Utilization of Glucose and Xylose by Sulfolobus acidocaldarius,” Journal of Bacteriology 193, 1293–1301.

Contact: Joseph Graber, SC-23.2, (301) 903-1239
Topic Areas:

  • Research Area: Genomic Analysis and Systems Biology
  • Research Area: Microbes and Communities
  • Research Area: Plant Systems and Feedstocks, Plant-Microbe Interactions
  • Research Area: Sustainable Biofuels and Bioproducts
  • Research Area: DOE Bioenergy Research Centers (BRC)
  • Research Area: Biosystems Design

Division: SC-23.2 Biological Systems Science Division, BER


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