U.S. Department of Energy Office of Biological and Environmental Research

BER Research Highlights


Understanding Microbial Tolerance to Next Generation Biofuels
Published: March 15, 2010
Posted: March 24, 2010

Short chain alcohols such as n-butanol are promising candidates as next generation biofuels because of their high energy density and compatibility with existing fuel supply infrastructure. Although several types of microbes can synthesize these compounds from biomass-derived sugars, their toxicity to the microbes limits the total quantities that can be produced. Scientists at the DOE Joint Bioenergy Institute (JBEI) have reported how exposure to n-butanol causes global changes in gene and protein expression in the model bacterium E. coli. Their studies provide clues on how the microbe regulates its response to this form of stress. These results identify new targets for reengineering microbes to improve their tolerance to n-butanol and other next generation biofuels. The research is published in the March 15th issue of Applied & Environmental Microbiology.

Reference: Rutherford, B. J., R. H. Dahl, R. E. Price, H. L. Szmidt, P. I. Benke, A. Muchopadhyay, and J. D. Keasling. 2010. "Functional Genomic Study of Exogenous n-Butanol Stress in Escherichia coli," Appl. & Environ. Microbiol. 76:1935-1945.

Contact: Joseph Graber, SC-23.2, (301) 903-1239
Topic Areas:

  • Research Area: Genomic Analysis and Systems Biology
  • Research Area: Microbes and Communities
  • Research Area: Sustainable Biofuels and Bioproducts
  • Research Area: DOE Bioenergy Research Centers (BRC)
  • Research Area: Biosystems Design

Division: SC-23.2 Biological Systems Science Division, BER

 

BER supports basic research and scientific user facilities to advance DOE missions in energy and environment. More about BER

Recent Highlights

May 10, 2019
Quantifying Decision Uncertainty in Water Management via a Coupled Agent-Based Model
Considering risk perception can improve the representation of human decision-making processes in age [more...]

May 09, 2019
Projecting Global Urban Area Growth Through 2100 Based on Historical Time Series Data and Future Scenarios
Study provides country-specific urban area growth models and the first dataset on country-level urba [more...]

May 05, 2019
Calibrating Building Energy Demand Models to Refine Long-Term Energy Planning
A new, flexible calibration approach improved model accuracy in capturing year-to-year changes in bu [more...]

May 03, 2019
Calibration and Uncertainty Analysis of Demeter for Better Downscaling of Global Land Use and Land Cover Projections
Researchers improved the Demeter model’s performance by calibrating key parameters and establi [more...]

Apr 22, 2019
Representation of U.S. Warm Temperature Extremes in Global Climate Model Ensembles
Representation of warm temperature events varies considerably among global climate models, which has [more...]

List all highlights (possible long download time)