U.S. Department of Energy Office of Biological and Environmental Research

BER Research Highlights


Addressing the Need for Trained Radiochemists - DOE Integrated Radiochemistry Research Projects of Excellence
Published: January 25, 2010
Posted: February 10, 2010

There is a national need for highly trained radiochemists to advance imaging science and its applications, both medical and nonmedical. DOE (BER) is addressing this need by funding graduate and post-graduate research trainees at six Integrated Radiochemistry Research Projects of Excellence. One project, the Integrated Manhattan Project for Excellence in Radiochemistry at the Memorial Sloan-Kettering Cancer Center, has just developed new radiochemistry methodologies using the positron-emitting radionuclide of zirconium-89 (89Zr). Postdoctoral trainee Jason P. Holland is working with Principal Investigator Jason S. Lewis to study the use of the 89Zr-radiolabeled antibody protein Trastuzumab (Herceptin) as a radiotracer. Holland's project has imaged the distribution of a mutated protein, human epidermal growth factor receptor-2 (HER2), that promotes the growth of breast cancer cells. These results demonstrate that their new radiochemistry methodology shows excellent potential for producing new radiotracers for the specific non-invasive delineation of HER2/neu positive breast tumors using positron emission tomography (PET). Their study has just been published in PLoS ONE.

References:

Holland JP, Caldos-Lopes E, Divilov V, Longo VA, Taldone T, Zatorska D, Chiosis G, Lewis JS. "Measuring the pharmacodynamic effects of a novel Hsp90 inhibitor on HER2/neu expression in mice using 89Zr-DFO-trastuzumab," PLoS One, January 25th, 2010, (Reference Link)

National Academies of Science Committee report, "Advancing Nuclear Medicine Through Innovation," published in September 2007.

Contact: Prem Srivastava, SC-23.2, (301) 903-4071
Topic Areas:

  • Cross-Cutting: Education
  • Legacy: Radiochemistry and Instrumentation

Division: SC-23.2 Biological Systems Science Division, BER

 

BER supports basic research and scientific user facilities to advance DOE missions in energy and environment. More about BER

Recent Highlights

Aug 24, 2019
New Approach for Studying How Microbes Influence Their Environment
A diverse group of scientists suggests a common framework and targeting of known microbial processes [more...]

Aug 08, 2019
Nutrient-Hungry Peatland Microbes Reduce Carbon Loss Under Warmer Conditions
Enzyme production in peatlands reduces carbon lost to respiration under future high temperatures. [more...]

Aug 05, 2019
Amazon Forest Response to CO2 Fertilization Dependent on Plant Phosphorus Acquisition
AmazonFACE Model Intercomparison. The Science Plant growth is dependent on the availabi [more...]

Jul 29, 2019
A Slippery Slope: Soil Carbon Destabilization
Carbon gain or loss depends on the balance between competing biological, chemical, and physical reac [more...]

Jul 15, 2019
Field Evaluation of Gas Analyzers for Measuring Ecosystem Fluxes
How gas analyzer type and correction method impact measured fluxes. The Science A side- [more...]

List all highlights (possible long download time)