BER launches Environmental System Science Program. Visit our new website under construction!

U.S. Department of Energy Office of Biological and Environmental Research

BER Research Highlights


Designing Aptamers to Control Chemical Reactions
Published: December 28, 2009
Posted: January 06, 2010

Aptamers are short single stranded molecules made up of nucleic acids (RNA and DNA) or peptides that bind, like antibodies, to specific target molecules. However, unlike antibodies they can be completely engineered and synthesized in a test tube for a variety of functions. Marit Nilsen-Hamilton's research group at the Ames Laboratory has led to a new approach for controlling metabolic pathways using aptamers. They discovered that it is possible to develop aptamers, using computational modeling of the aptamer structure, that completely protect target molecules from chemical modification. These results suggest that aptamers might be engineered for use inside cells to alter the flow of chemicals through metabolic pathways with the potential to alter plants or microbes for improved production of biofuels.

Reference: T. Wang, et al., "Computational and Experimental Analyses Converge to Reveal a Coherent Yet Malleable Aptamer Structure That Controls Chemical Reactivity," Journal of American Chemical Society (2009) 131, 14747-14755.

Contact: Prem Srivastava, SC-23.2, (301) 903-4071
Topic Areas:

  • Research Area: Genomic Analysis and Systems Biology
  • Research Area: Microbes and Communities
  • Research Area: Plant Systems and Feedstocks, Plant-Microbe Interactions
  • Research Area: Sustainable Biofuels and Bioproducts
  • Research Area: Biosystems Design
  • Research Area: Computational Biology, Bioinformatics, Modeling

Division: SC-33.2 Biological Systems Science Division, BER

 

BER supports basic research and scientific user facilities to advance DOE missions in energy and environment. More about BER

Recent Highlights

Mar 23, 2021
Molecular Connections from Plants to Fungi to Ants
Lipids transfer energy and serve as an inter-kingdom communication tool in leaf-cutter ants&rsqu [more...]

Mar 19, 2021
Microbes Use Ancient Metabolism to Cycle Phosphorus
Microbial cycling of phosphorus through reduction-oxidation reactions is older and more widespre [more...]

Feb 22, 2021
Warming Soil Means Stronger Microbe Networks
Soil warming leads to more complex, larger, and more connected networks of microbes in those soi [more...]

Jan 27, 2021
Labeling the Thale Cress Metabolites
New data pipeline identifies metabolites following heavy isotope labeling.

Analysis [more...]

Aug 31, 2020
Novel Bacterial Clade Reveals Origin of Form I Rubisco
Objectives

  • All plant biomass is sourced from the carbon-fixing enzyme Rub [more...]

List all highlights (possible long download time)