U.S. Department of Energy Office of Biological and Environmental Research

BER Research Highlights


DOE Animal Tissue Archive Makes Valuable Information Available to Scientific Community
Published: July 20, 2009
Posted: July 27, 2009

In the 1960-1990s the Department of Energy carried out a series of large-scale animal studies to understand the consequences of radiation exposure.  The exposures involved the use of over 7,000 beagle dogs and over 49,000 mice.  Tissues from these animals are now available in an archive and dataset that has been established (http://janus.northwestern.edu/wololab/).  With development of new molecular technologies in the decades since the completion of the original studies, it is possible to query these samples and datasets for new questions that could not be addressed previously.  Recent analysis of the databases and the tissues by investigators in the DOE Low Dose Radiation Research Program have turned up new findings regarding radiation toxicities including new gender-specific differences in radiation toxicities and protective capabilities of radioprotectors that had not been previously identified, including some examples where radiation had no effect on tumor induction.  Information on the tissue archive is available from Dr. Gayle Woloschak, Northwestern University; (312) 503-4322; g-woloschak@northwestern.edu

Contact: Noelle Metting, SC-23.2, (301) 903-8309
Topic Areas:

  • Legacy: Low Dose Radiation, Radiobiology

Division: SC-23.2 Biological Systems Science Division, BER

 

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