BER launches Environmental System Science Program. Visit our new website under construction!

U.S. Department of Energy Office of Biological and Environmental Research

BER Research Highlights


Defining the Role of Predictive Modeling for Rational Biological Engineering
Published: April 13, 2009
Posted: April 24, 2009

The field of genomics is moving toward rational re-engineering of microbes that could provide new technologies for DOE's energy and environment missions.  Nitin Baliga and co-authors at the Institute for Systems Biology (ISB) have just published an article in Nature Reviews Microbiology (Volume 7, pages 297-305, April 2009) that discusses current research in genomics and the opportunities for significant advances provided by the integration of new technologies such as synthetic biology, systems biology, and predictive modeling. The authors point out that biological systems do not readily adapt to large changes in their metabolic or regulatory systems that alter the balance of energy or resources.  New strategies are needed to overcome this obstacle that bring together separate efforts in systems biology and synthetic biology using simultaneous global modeling and systems optimization. This multi-scale approach to experimental characterization and redesign of microbial cells and microbial communities will provide a foundation for applying microbial biology to achieve new sources of energy and to solve problems in environmental contamination.

Contact: Susan Gregurick, SC-23.2, (301) 903-7672, Arthur Katz, SC-23.2. (301) 903-4932
Topic Areas:

  • Research Area: Subsurface Biogeochemical Research
  • Research Area: Genomic Analysis and Systems Biology
  • Research Area: Microbes and Communities
  • Research Area: Sustainable Biofuels and Bioproducts
  • Research Area: Biosystems Design
  • Research Area: Computational Biology, Bioinformatics, Modeling

Division: SC-33.2 Biological Systems Science Division, BER

 

BER supports basic research and scientific user facilities to advance DOE missions in energy and environment. More about BER

Recent Highlights

Mar 23, 2021
Molecular Connections from Plants to Fungi to Ants
Lipids transfer energy and serve as an inter-kingdom communication tool in leaf-cutter ants&rsqu [more...]

Mar 19, 2021
Microbes Use Ancient Metabolism to Cycle Phosphorus
Microbial cycling of phosphorus through reduction-oxidation reactions is older and more widespre [more...]

Feb 22, 2021
Warming Soil Means Stronger Microbe Networks
Soil warming leads to more complex, larger, and more connected networks of microbes in those soi [more...]

Jan 27, 2021
Labeling the Thale Cress Metabolites
New data pipeline identifies metabolites following heavy isotope labeling.

Analysis [more...]

Aug 31, 2020
Novel Bacterial Clade Reveals Origin of Form I Rubisco
Objectives

  • All plant biomass is sourced from the carbon-fixing enzyme Rub [more...]

List all highlights (possible long download time)