U.S. Department of Energy Office of Biological and Environmental Research

BER Research Highlights

Cheaper DNA Sequencing of Very Large Genomes
Published: October 27, 2008
Posted: January 27, 2009

Complete Genomics, Inc., has announced a new technology for sequencing extremely large genomes at low cost. The system is an evolution from DOE-funded sequencing research carried out at Argonne National Laboratory (ANL) in the 1990s by Rade Drmanac. He continued technology developments with a focus on cost reduction through miniaturization and multiplexing sequence readouts on target DNAs with support from the DOE SBIR program and other sources. Over the years, the scale of data readouts (and the corresponding need for expensive reagents) has gone from square meter membranes to the current implementation involving minute volumes of reagents on microscope slides. On these slides a target genome is redundantly represented as dense arrays of DNA mini-spheres. The new methodology could provide substantial cost reductions for DOE mission needs for sequencing plant genomes, that often are much larger than mammalian genomes. Drmanac's accomplish­ments are described in an article in the October 2008 issue of Nature Biotechnology, and the new instrumentation has been highlighted in an article in the October 6 issue of the New York Times.

Contact: Marvin Stodolsky, SC-23.2, (301) 903-4475
Topic Areas:

  • Research Area: Genomic Analysis and Systems Biology
  • Research Area: Plant Systems and Feedstocks, Plant-Microbe Interactions
  • Research Area: Sustainable Biofuels and Bioproducts
  • Research Area: Research Technologies and Methodologies

Division: SC-23.2 Biological Systems Science Division, BER


BER supports basic research and scientific user facilities to advance DOE missions in energy and environment. More about BER

Recent Highlights

May 10, 2019
Quantifying Decision Uncertainty in Water Management via a Coupled Agent-Based Model
Considering risk perception can improve the representation of human decision-making processes in age [more...]

May 09, 2019
Projecting Global Urban Area Growth Through 2100 Based on Historical Time Series Data and Future Scenarios
Study provides country-specific urban area growth models and the first dataset on country-level urba [more...]

May 05, 2019
Calibrating Building Energy Demand Models to Refine Long-Term Energy Planning
A new, flexible calibration approach improved model accuracy in capturing year-to-year changes in bu [more...]

May 03, 2019
Calibration and Uncertainty Analysis of Demeter for Better Downscaling of Global Land Use and Land Cover Projections
Researchers improved the Demeter model’s performance by calibrating key parameters and establi [more...]

Apr 22, 2019
Representation of U.S. Warm Temperature Extremes in Global Climate Model Ensembles
Representation of warm temperature events varies considerably among global climate models, which has [more...]

List all highlights (possible long download time)