U.S. Department of Energy Office of Biological and Environmental Research

BER Research Highlights

Journal of Structural Biology Cover Article on X-ray Imaging of Cells at Advanced Light Source (ALS)
Published: June 16, 2008
Posted: June 20, 2008

X-ray tomography has determined the structure of organelles in yeast cells during different stages of the cell cycle, providing for the first time three-dimensional images that show how the cells change during the cycle. The research is reported in the June issue of the Journal of Structural Biology, with selected images shown on the cover. The authors show that use of the soft X-rays at the ALS enables imaging of cellular components without having to expose the cells to potentially damaging staining reagents. They were able to determine how the yeast responds to changes in its environment. They note that the new X-ray microscope being commissioned at the ALS for biological studies will enable further improvements in spatial resolution that should reveal fine structure of microtubules and other components of the cell. This new imaging technique is ideally suited to imaging bioenergy-relevant organisms. The research was led by Dr. Carolyn A. Larabell of the Lawrence Berkeley National Laboratory and the University of California-San Francisco.

Contact: Roland F. Hirsch, SC-23.2, (301) 903-9009
Topic Areas:

  • Research Area: Sustainable Biofuels and Bioproducts
  • Research Area: Structural Biology, Biomolecular Characterization and Imaging
  • Research Area: Structural Biology Infrastructure
  • Research Area: Research Technologies and Methodologies

Division: SC-23.2 Biological Systems Science Division, BER
      (formerly SC-23.2 Medical Sciences Division, OBER)


BER supports basic research and scientific user facilities to advance DOE missions in energy and environment. More about BER

Recent Highlights

Aug 24, 2019
New Approach for Studying How Microbes Influence Their Environment
A diverse group of scientists suggests a common framework and targeting of known microbial processes [more...]

Aug 08, 2019
Nutrient-Hungry Peatland Microbes Reduce Carbon Loss Under Warmer Conditions
Enzyme production in peatlands reduces carbon lost to respiration under future high temperatures. [more...]

Aug 05, 2019
Amazon Forest Response to CO2 Fertilization Dependent on Plant Phosphorus Acquisition
AmazonFACE Model Intercomparison. The Science Plant growth is dependent on the availabi [more...]

Jul 29, 2019
A Slippery Slope: Soil Carbon Destabilization
Carbon gain or loss depends on the balance between competing biological, chemical, and physical reac [more...]

Jul 15, 2019
Field Evaluation of Gas Analyzers for Measuring Ecosystem Fluxes
How gas analyzer type and correction method impact measured fluxes. The Science A side- [more...]

List all highlights (possible long download time)