U.S. Department of Energy Office of Biological and Environmental Research

BER Research Highlights

Journal of Structural Biology Cover Article on X-ray Imaging of Cells at Advanced Light Source (ALS)
Published: June 16, 2008
Posted: June 20, 2008

X-ray tomography has determined the structure of organelles in yeast cells during different stages of the cell cycle, providing for the first time three-dimensional images that show how the cells change during the cycle. The research is reported in the June issue of the Journal of Structural Biology, with selected images shown on the cover. The authors show that use of the soft X-rays at the ALS enables imaging of cellular components without having to expose the cells to potentially damaging staining reagents. They were able to determine how the yeast responds to changes in its environment. They note that the new X-ray microscope being commissioned at the ALS for biological studies will enable further improvements in spatial resolution that should reveal fine structure of microtubules and other components of the cell. This new imaging technique is ideally suited to imaging bioenergy-relevant organisms. The research was led by Dr. Carolyn A. Larabell of the Lawrence Berkeley National Laboratory and the University of California-San Francisco.

Contact: Roland F. Hirsch, SC-23.2, (301) 903-9009
Topic Areas:

  • Research Area: Sustainable Biofuels and Bioproducts
  • Research Area: Structural Biology, Biomolecular Characterization and Imaging
  • Research Area: Structural Biology Infrastructure
  • Research Area: Research Technologies and Methodologies

Division: SC-23.2 Biological Systems Science Division, BER
      (formerly SC-23.2 Medical Sciences Division, OBER)


BER supports basic research and scientific user facilities to advance DOE missions in energy and environment. More about BER

Recent Highlights

May 10, 2019
Quantifying Decision Uncertainty in Water Management via a Coupled Agent-Based Model
Considering risk perception can improve the representation of human decision-making processes in age [more...]

May 09, 2019
Projecting Global Urban Area Growth Through 2100 Based on Historical Time Series Data and Future Scenarios
Study provides country-specific urban area growth models and the first dataset on country-level urba [more...]

May 05, 2019
Calibrating Building Energy Demand Models to Refine Long-Term Energy Planning
A new, flexible calibration approach improved model accuracy in capturing year-to-year changes in bu [more...]

May 03, 2019
Calibration and Uncertainty Analysis of Demeter for Better Downscaling of Global Land Use and Land Cover Projections
Researchers improved the Demeter model’s performance by calibrating key parameters and establi [more...]

Apr 22, 2019
Representation of U.S. Warm Temperature Extremes in Global Climate Model Ensembles
Representation of warm temperature events varies considerably among global climate models, which has [more...]

List all highlights (possible long download time)