U.S. Department of Energy Office of Biological and Environmental Research

BER Research Highlights

DOE-JGI Microbial Genome Sequencing Project Leads to the Discovery of a New Carbon Dioxide Fixation Pathway
Published: January 07, 2008
Posted: January 17, 2008

The December 14, 2007, issue of Science features a report that reveals a novel fifth pathway for carbon dioxide (CO2) fixation used by the archaeon, Metallosphaera sedula. The real significance of this new finding is that novel additional mechanisms exist in the microbial world for carbon capture and cycling; exploitation of these strategies may lead to new opportunities and technologies to address critical DOE missions in bioenergy and carbon biosequestration. The discovery of this new pathway, distinct from the four previously identified pathways for growth on CO2, including the well-known Calvin cycle that powers photosynthesis in plants and algae, was grounded in the sequencing of the genome of Metallosphaera sedula by the DOE Joint Genome Institute which provided the genetic "parts list" for comparison with genes known to be involved in the four previously known pathways for growth on CO2 as a sole carbon source. Additional genome comparisons revealed that a number of other microbes possess this new pathway and in surveying the Venter Global Ocean Sampling database, an unexpectedly large number of "5th-pathway" genes were observed, suggesting that this mechanism for carbon capture is much more widespread than suspected.

Reference: Ivan A. Berg, Daniel Kockelkorn, Wolfgang Buckel, and Georg Fuchs. 2007. Science 318(5857) 1782.

Contact: Dan Drell, SC-23.2, (301) 903-4742
Topic Areas:

  • Research Area: Carbon Cycle, Nutrient Cycling
  • Research Area: Genomic Analysis and Systems Biology
  • Research Area: Microbes and Communities
  • Research Area: DOE Joint Genome Institute (JGI)
  • Research Area: Sustainable Biofuels and Bioproducts

Division: SC-23.2 Biological Systems Science Division, BER
      (formerly SC-23.2 Medical Sciences Division, OBER)


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