U.S. Department of Energy Office of Biological and Environmental Research

BER Research Highlights


Tenth Annual Pezcoller Foundation-AACR International Award for Cancer Research
Published: March 26, 2007
Posted: April 24, 2007

The Tenth Annual Pezcoller Foundation-AACR International Award for Cancer Research will be given this year to Lawrence Berkeley National Laboratory Distinguished Scientist Mina Bissell. Dr. Bissell's seminal work revealed the critical importance of the cell microenvironment for normal cell function, and that multi-cellular interactions and extracellular signaling are integral rather than secondary factors in determining the development of cancer. Extensions of her research, funded by DOE's Low Dose Radiation Research Program, are showing parallel applicability in the field of radiation carcinogenesis. In the early years of research in tissue culture, it was assumed that cells growing sheets of one-cell thickness provided an adequate model for the body's tissue/organ functions. Bissell's work in this arena, begun in the 1980s, showed that monolayer cultures do not adequately model normal tissues. Using mouse breast cells in culture as the experimental model, she showed that 3-dimensional cellular aggregates much more closely mimic organ function and regulation. Dr. Bissell's pivotal contributions have been internationally recognized. The 2007 Pezcoller Award is her most recent and prestigious honor. Dr. Bissell will present the Award Lecture at the American Association for Cancer Research 98th Annual Meeting, April 14-18, 2007, in Los Angeles, entitled Phenotype overrides genotype in normal mammary gland and breast cancer. She will then present the Second Annual Stanley J. Korsmeyer Lecture in Padua, Italy, just prior to the official Award ceremony in Trento, Italy, in early May 2007.

Contact: Marvin Stodolsky, DOE SC-23.2, (301) 903-4475
Topic Areas:

  • Cross-Cutting: Lectures, Awards, and Recognition
  • Legacy: Low Dose Radiation, Radiobiology
  • Legacy: Medical Applications

Division: SC-23.2 Biological Systems Science Division, BER
      (formerly SC-23.2 Medical Sciences Division, OBER)

 

BER supports basic research and scientific user facilities to advance DOE missions in energy and environment. More about BER

Recent Highlights

May 10, 2019
Quantifying Decision Uncertainty in Water Management via a Coupled Agent-Based Model
Considering risk perception can improve the representation of human decision-making processes in age [more...]

May 09, 2019
Projecting Global Urban Area Growth Through 2100 Based on Historical Time Series Data and Future Scenarios
Study provides country-specific urban area growth models and the first dataset on country-level urba [more...]

May 05, 2019
Calibrating Building Energy Demand Models to Refine Long-Term Energy Planning
A new, flexible calibration approach improved model accuracy in capturing year-to-year changes in bu [more...]

May 03, 2019
Calibration and Uncertainty Analysis of Demeter for Better Downscaling of Global Land Use and Land Cover Projections
Researchers improved the Demeter model’s performance by calibrating key parameters and establi [more...]

Apr 22, 2019
Representation of U.S. Warm Temperature Extremes in Global Climate Model Ensembles
Representation of warm temperature events varies considerably among global climate models, which has [more...]

List all highlights (possible long download time)