U.S. Department of Energy Office of Biological and Environmental Research

BER Research Highlights


Publication from Low Dose Radiation Research Program Highlighted on Cover of Cancer Research
Published: January 01, 2007
Posted: January 17, 2007

Important new work from LBNL scientist Dr. Mary Helen Barcellos-Hoff demonstrates a previously unsuspected role for extracellular signaling by TGF-beta1 protein in the cellular response to DNA damage induced by ionizing radiation. The research, funded by both DOE and NASA, is testing the revolutionary idea that extracellular signaling controls DNA damage response. DNA damage elicits a cellular response program of damage control coordinated by the kinase activity of the ATM protein. Kirshner, et al., show that ATM activity, but not its abundance, is severely compromised in mouse cells in which the TGF-beta1 gene is deleted and in human epithelial cells in which TGF-beta1 signaling is blocked by an inhibitor. As a consequence of the failure of ATM to phosphorylate its substrates, cells exhibit increased radiosensitivity, as demonstrated by compromised radiation-induced apoptosis and cell-cycle arrest, and by increased cell kill measured in clonogenic assays. Future studies to identify the molecular mechanisms of TGF-beta1 protein inhibition may support the use of these inhibitors to increase response to radiotherapy. For details, see the cover article in the November 15, 2006, issue of Cancer Research, beginning on page 10861.

Contact: Noelle Metting, SC-23.2, (301) 903-8309
Topic Areas:

  • Legacy: Low Dose Radiation, Radiobiology
  • Legacy: Medical Applications

Division: SC-23.2 Biological Systems Science Division, BER
      (formerly SC-23.2 Medical Sciences Division, OBER)

 

BER supports basic research and scientific user facilities to advance DOE missions in energy and environment. More about BER

Recent Highlights

Aug 24, 2019
New Approach for Studying How Microbes Influence Their Environment
A diverse group of scientists suggests a common framework and targeting of known microbial processes [more...]

Aug 08, 2019
Nutrient-Hungry Peatland Microbes Reduce Carbon Loss Under Warmer Conditions
Enzyme production in peatlands reduces carbon lost to respiration under future high temperatures. [more...]

Aug 05, 2019
Amazon Forest Response to CO2 Fertilization Dependent on Plant Phosphorus Acquisition
AmazonFACE Model Intercomparison. The Science Plant growth is dependent on the availabi [more...]

Jul 29, 2019
A Slippery Slope: Soil Carbon Destabilization
Carbon gain or loss depends on the balance between competing biological, chemical, and physical reac [more...]

Jul 15, 2019
Field Evaluation of Gas Analyzers for Measuring Ecosystem Fluxes
How gas analyzer type and correction method impact measured fluxes. The Science A side- [more...]

List all highlights (possible long download time)