U.S. Department of Energy Office of Biological and Environmental Research

BER Research Highlights

Office of Science Researcher on Cover of March 2006 Issue of Molecular Microbiology
Published: March 13, 2006
Posted: March 22, 2006

Dr. Huilin Li, BNL, and his collaborators were featured on the cover of Molecular Microbiology for producing a series of structures of a protein destroying molecular machine called the proteosome. The proteosomes ability to rapidly degrade proteins is essential for the microbial cells ability to adjust to its environment by removing proteins that could interfere with the performance of newly produced molecular machines as well as disposing of cellular trash such as misfolded or inactive proteins or pieces. Dr. Li and his associates cryo- electron microscopy images reveal the cylindrical proteosome has closed ends, in contrast to x-ray crystallography data that had indicated an unstructured open form, and therefore poses new questions about how this machine works. The cryo-electron microscopy studies were supported by Genomics:GTL funding as part of research developing imaging techniques to be applied to the study of microbial molecular machines.

Contact: Arthur Katz, SC-23.2, (301) 903-4932
Topic Areas:

  • Research Area: Genomic Analysis and Systems Biology
  • Research Area: Microbes and Communities
  • Research Area: Structural Biology, Biomolecular Characterization and Imaging
  • Research Area: Research Technologies and Methodologies

Division: SC-23.2 Biological Systems Science Division, BER
      (formerly SC-23.2 Medical Sciences Division, OBER)


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