U.S. Department of Energy Office of Biological and Environmental Research

BER Research Highlights


Berkeley Lab Research on Three-Dimensional Cell Culture Featured in Nature
Published: August 27, 2003
Posted: September 05, 2003

Much research in the life sciences involves culturing cells in the laboratory using a growth medium in which the cells arrange themselves in flat two-dimensional (2-D) layers. But cells in living organisms are arranged in three dimensional complexes (3-D). Research by Mina Bissell and colleagues at the Lawrence Berkeley National Laboratory (LBNL) has pioneered ways to culture cells in the laboratory in a 3-D arrangement enabling studies of how cells behave in the organism. They have used these 3-D culture conditions to show how normal and breast cancer cells differ in 3-D, to screen for environmental insults and drugs to reverse the malignant phenotype, and to show that cells in 3-D cultures can have significantly different responses to antibodies from those of the same cells in 2-D cultures. The LBNL research is described in a feature article ("Biology's new dimension") in the August 21, 2003, issue of Nature. The article discusses findings at LBNL on the behavior of breast cancer cells and includes a photograph of the laboratory where the research is being done.

Contact: Roland F. Hirsch, SC-73, (301) 903-9009
Topic Areas:

  • Research Area: Structural Biology, Biomolecular Characterization and Imaging
  • Legacy: Medical Applications

Division: SC-23.2 Biological Systems Science Division, BER
      (formerly SC-73 Medical Sciences Division, OBER)

 

BER supports basic research and scientific user facilities to advance DOE missions in energy and environment. More about BER

Recent Highlights

Aug 24, 2019
New Approach for Studying How Microbes Influence Their Environment
A diverse group of scientists suggests a common framework and targeting of known microbial processes [more...]

Aug 08, 2019
Nutrient-Hungry Peatland Microbes Reduce Carbon Loss Under Warmer Conditions
Enzyme production in peatlands reduces carbon lost to respiration under future high temperatures. [more...]

Aug 05, 2019
Amazon Forest Response to CO2 Fertilization Dependent on Plant Phosphorus Acquisition
AmazonFACE Model Intercomparison. The Science Plant growth is dependent on the availabi [more...]

Jul 29, 2019
A Slippery Slope: Soil Carbon Destabilization
Carbon gain or loss depends on the balance between competing biological, chemical, and physical reac [more...]

Jul 15, 2019
Field Evaluation of Gas Analyzers for Measuring Ecosystem Fluxes
How gas analyzer type and correction method impact measured fluxes. The Science A side- [more...]

List all highlights (possible long download time)