U.S. Department of Energy Office of Biological and Environmental Research

BER Research Highlights


Biological and Environmental Research Low Dose Radiation Research Program Releases Innovative Risk Modeling Call
Published: March 12, 2003
Posted: March 25, 2003

The Low Dose Program has just published Notices 03-20 and LAB03-20: Biologically-Based Risk Modeling, an innovative approach to begin the process of considering the various strategies for using the new experimental data now coming out of the Program. Successful awardees will participate in a biologically-based risk modeling exercise, for the purposes of developing and evaluating different modeling/prediction strategies. A central aspect of this exercise will be the eventual modeling, by all awardees, of an artificially defined biological test system or archetype having a set of biological characteristics and radiation-induced endpoints for which exact probability values are either known or assigned. The long term goals of this exercise are to discover which mechanistic data are usable and which are the most critical inputs for development of biologically-based models to predict human health risks for low dose exposures (the exercise thus may help to define future experimental research needs) and to provide new insight into how to extrapolate between different levels of biological organization (from molecules to cells to tissues to organisms) and from observations in vitro to biological responses in vivo. Formal applications are due by May 23, 2003.

Contact: Noelle Metting, SC-72, (301) 903-8309
Topic Areas:

  • Legacy: Low Dose Radiation, Radiobiology

Division: SC-23.2 Biological Systems Science Division, BER
      (formerly SC-72 Life Sciences Division, OBER)

 

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