U.S. Department of Energy Office of Biological and Environmental Research

BER Research Highlights


Fallypride: PET Imaging Radiopharmaceutical Agent for Accurate Measurement of Dopamine Receptor Protein Concentration in the Living Human Brain
Published: September 11, 2002
Posted: September 30, 2002

It has not been possible to image the receptor protein nanoscopic concentrations in the human brain. With the support of the Office of Science's BER Radiopharmaceutical Development Program, Dr. Jogesh Mukherjee and colleagues have developed "fallypride," a unique fluorine-18-radiolabeled positron emission tomography (PET) imaging agent, for non-invasively measuring the dopamine receptor protein concentration in the human brain. Accurate measurement of receptor protein at nanoscopic concentrations is considered critical for evaluating efficacy of therapeutic drugs for mental illness, understanding disease mechanisms such as schizophrenia, alcoholism and stress, evaluate effects of drugs of abuse in crucial brain areas and study deficits in cognition during aging and in Alzheimer's disease. These studies using fallypride are currently ongoing at various imaging centers in the U.S. and in Europe. The first paper on the human use of fallypride by Dr. Mukherjee and colleagues appeared in the September issue of the journal Synapse (46,17-188, 2002). Dr. Mukherjee is currently at the University of California, Irvine.

Contact: Prem C. Srivastava, SC-73, 3-4071
Topic Areas:

  • Legacy: Radiochemistry and Instrumentation
  • Legacy: Medical Applications

Division: SC-23.2 Biological Systems Science Division, BER
      (formerly SC-73 Medical Sciences Division, OBER)

 

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