U.S. Department of Energy Office of Biological and Environmental Research

BER Research Highlights


BER Scientists to receive American Chemical Society National Awards in 2002.
Published: September 05, 2001
Posted: September 14, 2001

Three DOE Biological and Environmental Research (BER) scientists are to receive American Chemical Society (ACS) awards at the ACS National Meeting in Orlando, Florida, April 9, 2002. Dr. Joanna Fowler, a senior chemist at Brookhaven National Laboratory, will receive the Glen T. Seaborg Award For Nuclear Chemistry. Dr. Roger Y. Tsien, a chemistry, biochemistry, and pharmacology professor at the Howard Hughes Medical Institute at the University of California, San Diego, will receive the ACS Award for Creative Invention. Edward S. Yeung of the Ames Laboratory will receive the ACS Award in Chromatography. The awards are announced in the August 27, 2001, issue of Chemical & Engineering News. Through her pioneering work in radiotracer chemistry research, Dr. Fowler has contributed substantially to the medical applications and clinical use of positron emission tomography (PET) throughout the world. PET, a nuclear medicine imaging technology, provides for non-invasive detection of biochemical transformations and the movement of drugs in the body. Dr. Fowler has contributed key applications of PET radiotracers in understanding the biochemical basis of addictive disorders including nicotine, alcohol, and many illicit drugs. Her research endeavors have been at the forefront of developing many new radiotracers including fluorine-18-fluorodeoxyglucose (FDG). These radiotracers have now become major scientific and clinical tools for non-invasively imaging glucose metabolism, brain dopamine signaling systems, and the levels of dopamine destructive enzyme monoamine oxidase (MAO) in the human brain. Dr. Yeung has been funded by BER for research in gene sequencing instrumentation since early in the Human Genome Program. He currently is studying high throughput techniques for detecting small differences between large DNA fragments. These differences can be due to mutations as simple as a single base being changed or as complex as deletion of long segments from one of the DNA samples being compared. Fast, accurate detection of mutations would enable more reliable determination of the genetic basis of variation of the biology within a population of organisms. Dr. Yeung's BER research makes use of fundamental advances in analytical chemistry developed by his research group with funding from the Office of Basic Energy Sciences. Dr. Tsien is a recent BER Medical Sciences program grantee. The long-term objectives of Dr. Tsien's research are to develop general ways to noninvasively image the expression of arbitrarily chosen genes within living organisms, eventually including human patients for medical applications.

Contact: Prem C. Srivastava, SC-73, 3-4071
Topic Areas:

  • Research Area: Genomic Analysis and Systems Biology
  • Research Area: Research Technologies and Methodologies
  • Cross-Cutting: Lectures, Awards, and Recognition
  • Legacy: Human Genome Project (1990-2003)
  • Legacy: Radiochemistry and Instrumentation

Division: SC-23.2 Biological Systems Science Division, BER
      (formerly SC-73 Medical Sciences Division, OBER)

 

BER supports basic research and scientific user facilities to advance DOE missions in energy and environment. More about BER

Recent Highlights

Aug 24, 2019
New Approach for Studying How Microbes Influence Their Environment
A diverse group of scientists suggests a common framework and targeting of known microbial processes [more...]

Aug 08, 2019
Nutrient-Hungry Peatland Microbes Reduce Carbon Loss Under Warmer Conditions
Enzyme production in peatlands reduces carbon lost to respiration under future high temperatures. [more...]

Aug 05, 2019
Amazon Forest Response to CO2 Fertilization Dependent on Plant Phosphorus Acquisition
AmazonFACE Model Intercomparison. The Science Plant growth is dependent on the availabi [more...]

Jul 29, 2019
A Slippery Slope: Soil Carbon Destabilization
Carbon gain or loss depends on the balance between competing biological, chemical, and physical reac [more...]

Jul 15, 2019
Field Evaluation of Gas Analyzers for Measuring Ecosystem Fluxes
How gas analyzer type and correction method impact measured fluxes. The Science A side- [more...]

List all highlights (possible long download time)