U.S. Department of Energy Office of Biological and Environmental Research

BER Research Highlights


Second International Structural Genomics Meeting Addresses Issues and Plans a Permanent International Organization.
Published: April 18, 2001
Posted: August 03, 2001

The meeting was held April 4-6, 2001, at Airlie House in Warrenton, Virginia. These meetings are addressing the major policy issues surrounding structural genomics programs around the world. The participants include representatives of the government agencies and private sector organizations in the U.S., Asia, and Europe that are funding structural genomics and of the major laboratories involved in the projects.

The field of structural genomics seeks high throughput inexpensive determination of the structures of large numbers of proteins using x-ray crystallography at synchrotrons as well as nuclear magnetic resonance spectrometry and other techniques. The increasing numbers of complete genome sequences becoming available makes it now essential to be able to determine the structures of proteins coded for by these genomes. Structural genomics was formally initiated at a meeting organized by BER's Structural Biology Center at Argonne National Laboratory in January 1998.

The participants adopted a statement of "Agreed Principles and Procedures." This document states the goals of structural genomics, outlines the new methods that need to be developed to achieve the goals, identifies issues of cooperation among the laboratories and among the agencies, addresses publication of the new structures achieved in structural genomics projects, and discusses intellectual property rights. The latter two issues are proving especially complicated, as some participants strongly favor immediate publication of structures once they are refined, while others are equally concerned with protecting potential patent rights that would in certain countries be compromised by publication of the structures.

The group decided to develop a more formal structure by forming an international organization for structural genomics. The organization would coordinate application of resources and rapid dissemination of new methodologies and results, promote access to unique resources such as synchrotrons and high field nuclear magnetic resonance facilities, and serve as a forum for developing policies, standards, and data formats for structural genomics worldwide. An Executive Committee was elected to develop the new organization. Tom Terwilliger of DOE's Los Alamos National Laboratory was chosen to represent the United States, along with scientists from Japan and Germany representing their parts of the world. The participants also decided to hold the next meeting in Berlin, Germany, in October 2002.

Contact: Roland Hirsch, SC-73, 3-9009
Topic Areas:

  • Research Area: Structural Biology, Biomolecular Characterization and Imaging
  • Research Area: Structural Biology Infrastructure

Division: SC-23.2 Biological Systems Science Division, BER
      (formerly SC-73 Medical Sciences Division, OBER)

 

BER supports basic research and scientific user facilities to advance DOE missions in energy and environment. More about BER

Recent Highlights

May 10, 2019
Quantifying Decision Uncertainty in Water Management via a Coupled Agent-Based Model
Considering risk perception can improve the representation of human decision-making processes in age [more...]

May 09, 2019
Projecting Global Urban Area Growth Through 2100 Based on Historical Time Series Data and Future Scenarios
Study provides country-specific urban area growth models and the first dataset on country-level urba [more...]

May 05, 2019
Calibrating Building Energy Demand Models to Refine Long-Term Energy Planning
A new, flexible calibration approach improved model accuracy in capturing year-to-year changes in bu [more...]

May 03, 2019
Calibration and Uncertainty Analysis of Demeter for Better Downscaling of Global Land Use and Land Cover Projections
Researchers improved the Demeter model’s performance by calibrating key parameters and establi [more...]

Apr 22, 2019
Representation of U.S. Warm Temperature Extremes in Global Climate Model Ensembles
Representation of warm temperature events varies considerably among global climate models, which has [more...]

List all highlights (possible long download time)