U.S. Department of Energy Office of Biological and Environmental Research

BER Research Highlights


Cover Article in Chemical & Engineering News Features Structure-Based Drug Design.
Published: June 06, 2001
Posted: August 03, 2001

The June 4 issue of Chemical & Engineering News, published by the American Chemical Society, has a feature article on structure-based drug design. The article emphasizes the importance of the Department of Energy synchrotron light sources to the effort to design candidate pharmaceuticals using structural information on large molecules. Structures are needed not only of the target proteins but also of complexes between the proteins and potential drugs. Structures obtained by x-ray crystallography, as well as nuclear magnetic resonance and mass spectrometry, also serve as input into computational structure modeling. Two of the companies whose research efforts are featured in the article, Syrrx and Structural Genomix, participate in dedicated synchrotron beam lines for high throughput crystallography, at the Advanced Light Source at the Berkeley Lab and the Advanced Photon Source at Argonne National Laboratory, respectively.

Contact: Roland Hirsch, SC-73, 3-9009
Topic Areas:

  • Research Area: Structural Biology, Biomolecular Characterization and Imaging
  • Research Area: Structural Biology Infrastructure

Division: SC-23.2 Biological Systems Science Division, BER
      (formerly SC-73 Medical Sciences Division, OBER)

 

BER supports basic research and scientific user facilities to advance DOE missions in energy and environment. More about BER

Recent Highlights

Aug 24, 2019
New Approach for Studying How Microbes Influence Their Environment
A diverse group of scientists suggests a common framework and targeting of known microbial processes [more...]

Aug 08, 2019
Nutrient-Hungry Peatland Microbes Reduce Carbon Loss Under Warmer Conditions
Enzyme production in peatlands reduces carbon lost to respiration under future high temperatures. [more...]

Aug 05, 2019
Amazon Forest Response to CO2 Fertilization Dependent on Plant Phosphorus Acquisition
AmazonFACE Model Intercomparison. The Science Plant growth is dependent on the availabi [more...]

Jul 29, 2019
A Slippery Slope: Soil Carbon Destabilization
Carbon gain or loss depends on the balance between competing biological, chemical, and physical reac [more...]

Jul 15, 2019
Field Evaluation of Gas Analyzers for Measuring Ecosystem Fluxes
How gas analyzer type and correction method impact measured fluxes. The Science A side- [more...]

List all highlights (possible long download time)