BER launches Environmental System Science Program. Visit our new website under construction!

U.S. Department of Energy Office of Biological and Environmental Research

BER Research Highlights

Nuclear Architecture and Gene Expression
Published: November 09, 2012
Posted: March 26, 2013

Gene positioning and regulation of nuclear architecture are thought to influence gene expression. Soft X-ray tomography (SXT) imaging shows that silent olfactory receptor (OR) genes from different chromosomes in mouse olfactory neurons converge in a small number of heterochromatic foci. These foci are OR exclusive and form in a differentiation-dependent manner specific to cell type. OR gene aggregation is developmentally synchronous with the downregulation of the lamin B receptor (LBR) and can be reversed by ectopic LBR expression in mature olfactory neurons. LBR-induced reorganization of nuclear architecture and disruption of OR aggregates perturbs the singularity of OR transcription and disrupts the olfactory neurons’ targeting specificity. These observations indicate spatial sequestering of heterochromatinized OR family members as a basis of monogenic and monoallelic gene expression. This research was conducted using resources at the Advanced Light Source at Lawrence Berkeley National Laboratory.

Reference: Clowney, E. J., et al. 2012. “Nuclear Aggregation of Olfactory Receptor Genes Governs Their Monogenic Expression,” Cell 151, 724–37. (Reference link)

Contact: Roland F. Hirsch, SC-23.2, (301) 903-9009
Topic Areas:

  • Research Area: Structural Biology, Biomolecular Characterization and Imaging
  • Research Area: Structural Biology Infrastructure

Division: SC-33.2 Biological Systems Science Division, BER


BER supports basic research and scientific user facilities to advance DOE missions in energy and environment. More about BER

Recent Highlights

Mar 23, 2021
Molecular Connections from Plants to Fungi to Ants
Lipids transfer energy and serve as an inter-kingdom communication tool in leaf-cutter ants&rsqu [more...]

Mar 19, 2021
Microbes Use Ancient Metabolism to Cycle Phosphorus
Microbial cycling of phosphorus through reduction-oxidation reactions is older and more widespre [more...]

Feb 22, 2021
Warming Soil Means Stronger Microbe Networks
Soil warming leads to more complex, larger, and more connected networks of microbes in those soi [more...]

Jan 27, 2021
Labeling the Thale Cress Metabolites
New data pipeline identifies metabolites following heavy isotope labeling.

Analysis [more...]

Aug 31, 2020
Novel Bacterial Clade Reveals Origin of Form I Rubisco

  • All plant biomass is sourced from the carbon-fixing enzyme Rub [more...]

List all highlights (possible long download time)