U.S. Department of Energy Office of Biological and Environmental Research

BER Research Highlights


Understanding the Roles Played by Hydrosulphide Membrane Channel and Its Relatives in Living Systems
Published: March 11, 2012
Posted: March 26, 2013

The hydrosulphide ion (HS–), a critical element in the origin of life on Earth, is important in physiology and cellular signaling. The HS– species is also the terminal product when an anaerobic bacterium derives its oxidative power from sulphate instead of oxygen. A recent study conducted on beamlines at the National Synchrotron Light Source revealed the structure of the hydrosulphide ion channel (HSC), a membrane-pore molecule, elucidating how HS– is able to escape from pathogenic Clostridium difficile cells. In the same protein family, the formate channel (FocA), which has a fold similar to HSC, has been shown to play two other roles related to bioenergy and environmental science. In the first case, hydrogen gas production in Escherichia coli depends on the selective decomposition of formate, whose concentration depends on FocA. In the second, when Euglena experiences long-term chronic exposure to cadmium ions, it overexpresses a FocA protein. This protein has been proposed as a marker for long-lasting cadmium pollution in water.

Reference: Czyzewski, B. K., and D.-N. Wang. 2012. “Identification and Characterization of a Bacterial Hydrosulphide Ion Channel,” Nature 483, 494–97. (Reference link)

Contact: Roland F. Hirsch, SC-23.2, (301) 903-9009
Topic Areas:

  • Research Area: Microbes and Communities
  • Research Area: Sustainable Biofuels and Bioproducts
  • Research Area: Structural Biology, Biomolecular Characterization and Imaging
  • Research Area: Structural Biology Infrastructure

Division: SC-23.2 Biological Systems Science Division, BER

 

BER supports basic research and scientific user facilities to advance DOE missions in energy and environment. More about BER

Recent Highlights

May 10, 2019
Quantifying Decision Uncertainty in Water Management via a Coupled Agent-Based Model
Considering risk perception can improve the representation of human decision-making processes in age [more...]

May 09, 2019
Projecting Global Urban Area Growth Through 2100 Based on Historical Time Series Data and Future Scenarios
Study provides country-specific urban area growth models and the first dataset on country-level urba [more...]

May 05, 2019
Calibrating Building Energy Demand Models to Refine Long-Term Energy Planning
A new, flexible calibration approach improved model accuracy in capturing year-to-year changes in bu [more...]

May 03, 2019
Calibration and Uncertainty Analysis of Demeter for Better Downscaling of Global Land Use and Land Cover Projections
Researchers improved the Demeter model’s performance by calibrating key parameters and establi [more...]

Apr 22, 2019
Representation of U.S. Warm Temperature Extremes in Global Climate Model Ensembles
Representation of warm temperature events varies considerably among global climate models, which has [more...]

List all highlights (possible long download time)