U.S. Department of Energy Office of Biological and Environmental Research

BER Research Highlights

Researchers Find First Gene for Crohn's Disease on Human Chromosome 16.
Published: May 30, 2001
Posted: August 03, 2001

Crohn's Disease results from an autoimmune attack on cells in the lower intestine. This form of inflammatory bowel disease is usually treated with steroids (to suppress the immune response) or surgery (to remove inflamed sections of the bowel that no longer participate in the digestion of foods and their absorption into the bloodstream). Two teams of scientists, one in the U.S. and another in France, have independently identified a candidate gene that is involved in the onset of Crohn's Disease. This gene, Nod2, is located on chromosome 16, which was sequenced by the DOE Joint Genome Institute. The Nod2 gene is found primarily in monocytes, simple defensive cells of the innate immune system. A mutation in this gene is found twice as frequently in Crohn's Disease patients as in nonaffected people. This mutation is thought to compromise the ability of monocytes to respond to bacteria that may contribute to the onset of this condition due to an excessive response by a different part of the immune system. The identification of this gene will give researchers a starting place to elucidate the mechanisms behind this inflammatory bowel disease.

Contact: Dan Drell, SC-72, 3-4742
Topic Areas:

  • Research Area: Genomic Analysis and Systems Biology
  • Research Area: DOE Joint Genome Institute (JGI)
  • Legacy: Human Genome Project (1990-2003)

Division: SC-23.2 Biological Systems Science Division, BER
      (formerly SC-72 Life Sciences Division, OBER)


BER supports basic research and scientific user facilities to advance DOE missions in energy and environment. More about BER

Recent Highlights

May 10, 2019
Quantifying Decision Uncertainty in Water Management via a Coupled Agent-Based Model
Considering risk perception can improve the representation of human decision-making processes in age [more...]

May 09, 2019
Projecting Global Urban Area Growth Through 2100 Based on Historical Time Series Data and Future Scenarios
Study provides country-specific urban area growth models and the first dataset on country-level urba [more...]

May 05, 2019
Calibrating Building Energy Demand Models to Refine Long-Term Energy Planning
A new, flexible calibration approach improved model accuracy in capturing year-to-year changes in bu [more...]

May 03, 2019
Calibration and Uncertainty Analysis of Demeter for Better Downscaling of Global Land Use and Land Cover Projections
Researchers improved the Demeter model’s performance by calibrating key parameters and establi [more...]

Apr 22, 2019
Representation of U.S. Warm Temperature Extremes in Global Climate Model Ensembles
Representation of warm temperature events varies considerably among global climate models, which has [more...]

List all highlights (possible long download time)