U.S. Department of Energy Office of Biological and Environmental Research

BER Research Highlights


Structure of Essential Malaria Parasite Enzyme Determined
Published: November 23, 2011
Posted: February 24, 2012

The three-dimensional structures of proteins and other macromolecules often provide a starting point for designing new approaches to solving problems in a wide range of applications from bioenergy to medicine. The high-resolution structure of a specific protein can be used to identify small molecules that would bind to the protein and increase or decrease its activity to achieve a desired change in a biological system. A new study has determined the structures of an enzyme found in the malaria parasite (Plasmodium falciparum). The enzyme is not found in humans but is required by the parasite for the formation of its outer membrane. Several high-resolution structures were obtained for the enzyme in several stages of its functioning as well as with a small molecule that inhibits it. The structural information helped identify the enzyme’s active site and will be used as a starting point to seek drugs to treat infections by the malaria parasite. The results, published in the Journal of Biological Chemistry, were obtained by scientists from Washington University at the highly productive beamline 19ID of the DOE Structural Biology Center at Argonne National Laboratory’s Advanced Photon Source.

Reference: Lee, S. G., Y. Kim, T. D. Alpert, A. Nagata, and J. M. Jez. 2012. "Structure and Reaction Mechanism of Phosphoethanolamine Methyltransferase from the Malaria Parasite Plasmodium falciparum," Journal of Biological Chemistry 287, 1426-1434, DOI: 10.1074/jbcM111.315267. (Reference link)

Contact: Roland F. Hirsch, SC-23.2, (301) 903-9009
Topic Areas:

  • Research Area: Structural Biology, Biomolecular Characterization and Imaging
  • Research Area: Structural Biology Infrastructure

Division: SC-23.2 Biological Systems Science Division, BER

 

BER supports basic research and scientific user facilities to advance DOE missions in energy and environment. More about BER

Recent Highlights

May 10, 2019
Quantifying Decision Uncertainty in Water Management via a Coupled Agent-Based Model
Considering risk perception can improve the representation of human decision-making processes in age [more...]

May 09, 2019
Projecting Global Urban Area Growth Through 2100 Based on Historical Time Series Data and Future Scenarios
Study provides country-specific urban area growth models and the first dataset on country-level urba [more...]

May 05, 2019
Calibrating Building Energy Demand Models to Refine Long-Term Energy Planning
A new, flexible calibration approach improved model accuracy in capturing year-to-year changes in bu [more...]

May 03, 2019
Calibration and Uncertainty Analysis of Demeter for Better Downscaling of Global Land Use and Land Cover Projections
Researchers improved the Demeter model’s performance by calibrating key parameters and establi [more...]

Apr 22, 2019
Representation of U.S. Warm Temperature Extremes in Global Climate Model Ensembles
Representation of warm temperature events varies considerably among global climate models, which has [more...]

List all highlights (possible long download time)